ZIA CP010128 01063 (ZIA) | |||
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Title | FIT - Bone mineral density and subsequent cancer risk | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Trabert, Britton | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $143,305 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (100.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (50.0%) Colon/Rectum (25.0%) Lung (5.0%) Uterine (20.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Several large cohort studies have demonstrated reduced breast cancer risks among women with a history of fractures or low bone mineral density (BMD). The impact of the severity and timing of bone loss on risk has not yet been investigated, and the extent to which other risk factors (family history, anthropometric factors, physical activity, and exogenous hormones) modify the relationship with BMD is unknown. This study aims to investigate whether BMD of the proximal femur predicts breast cancer risk; whether breast cancer risk factors among postmenopausal women modify the relationship with BMD; whether BMD predicts endometrial or other cancers; and whether measurable biomarkers offer further etiologic clues about BMD and cancer risk. To date, analyses have been undertaken to assess the relationship of adipocytokines to endometrial cancer risk. Further, estrogen metabolites have been measured and have been assessed in relation to breast, endometrial, ovarian, and colorectal cancer risk. Ongoing analyses are assessing roles of androgens and progesterone in cancer risk. |