Title |
Cancer Center Support Grant
|
Institution |
VANDERBILT UNIVERSITY, NASHVILLE, TN
|
Principal Investigator |
PIETENPOL, JENNIFER
|
NCI Program Director |
PIETENPOL
|
Cancer Activity |
Multidisciplinary
|
Division |
OCC
|
Funded Amount |
$60,000
|
Project Dates |
09/17/1997 - 08/31/2018
|
Fiscal Year |
2015
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Basic Behavioral and Social Science (3.0%)
Behavioral and Social Science (6.0%)
Biochemical Epidemiology (23.0%)
Bioengineering (3.0%)
Cancer (100.0%)
Cancer Survivorship (3.0%)
Chemoprevention (4.0%)
Chemotherapy (9.0%)
Childhood Cancers (2.0%)
Digestive Diseases (34.0%)
Genetic Testing (3.0%)
Metastasis (19.0%)
Nuclear Magnetic Resonance Imaging (NMR) (6.0%)
Smoking Behavior (3.0%)
Surgery (1.0%)
Taxol (1.0%)
|
Brain (5.0%)
Breast (27.0%)
Colon/Rectum (17.0%)
Esophagus (3.0%)
Head and Neck (1.0%)
Kidney Cancer (1.0%)
Kidney Disease (1.0%)
Leukemia (1.0%)
Liver Cancer (3.0%)
Lung (14.0%)
Melanoma (1.0%)
Non Hodgkins Lymphoma (2.0%)
Prostate (3.0%)
Stomach (11.0%)
Uterine (1.0%)
Sarcoma (1.0%)
|
Research Type |
Cancer Initiation: Alterations in Chromosomes
Resources and Infrastructure Related to Etiology
Resources and Infrastructure Related to Prevention
Resources and Infrastructure Related to Detection, Diagnosis, or Prognosi
Resources and Infrastructure Related to Treatment and the Prevention of Recurrence
Resources and Infrastructure Related to Cancer Control, Survivorship, and Outcomes Researc
|
Abstract |
DESCRIPTION (provided by applicant): Cancer is a genetic disease caused by mutations, chromosomal abnormalities and chromatin changes that alter gene expression and protein function. This simple statement is the foundation of the Genome Maintenance Research Program (GM). GM is a cohesive network of basic science researchers whose collective mission is to understand processes affecting the integrity, expression and duplication of genetic material. This mission consists not only of explaining the etiology of cancer, but also understanding how existing therapeutics work, and identifying opportunities for new therapeutic development. The Program promotes the highest level of scientific discovery by fostering interactions among members, educating members on opportunities for collaborative research with other programs, and serving as a genome-centric resource for the entire Vanderbilt-Ingram Cancer Center (VICC). Research interests of GM members include carcinogen metabolism, DNA metabolism, DNA damage responses, chromatin and gene expression, epigenetics, and the cell division cycle. There are 26 program members of GM from 11 departments and two schools, with $5.4M in NCI funding and $7M in other peer-reviewed cancer-related funding. Out of 399 publications, 15% are intra-programmatic and 21% are inter-programmatic. Members also have 160 collaborative publications with investigators at other institutions. " |