ZIA BC 011478 (ZIA) | |||
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Title | Tumor infiltrating lymphocyte therapy for human papillomavirus-positive cancers | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hinrichs, Christian | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $197,133 | Project Dates | 10/01/2012 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Digestive Diseases (21.0%) |
Anus (21.0%) Cervical Cancer (48.0%) Head and Neck (25.0%) Penis (2.0%) Pharynx (25.0%) Vaginal (2.0%) |
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Research Type | |||
Systemic Therapies - Discovery and Development Systemic Therapies - Clinical Applications |
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Abstract | |||
The purpose of this project is to determine the objective clinical response rate of TIL therapy in HPV-positive cancers and to investigate the specificity, phenotype, and function of TIL from HPV-positive cancers in vitro and in vivo. Our laboratory has established the feasibility of generating TIL from HPV-positive cancers at clinical grade and scale. Based on that work we have initiated a clinical trial of TIL from HPV-positive cancers (HPV-TIL) with the primary end point of objective clinical response rate. The trial is open to accrual at this time. Laboratory studies to characterize HPV-TIL and to innovate the next generate of cellular therapies for this family of diseases are ongoing." |