ZIA BC 011192 (ZIA) | |||
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Title | The Mechanism of Thymic Lymphomagenesis in Genetically Engineered Mouse Model | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Van Dyke, Terry | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $222,556 | Project Dates | 10/01/2008 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) |
Hodgkins disease (50.0%) Non Hodgkins Lymphoma (50.0%) |
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Research Type | |||
Cancer Initiation: Oncogenes and Tumor Suppressor Genes Cancer Progression and Metastasis |
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Abstract | |||
We have crossed K18 mouse to several different Cre lines (e.g. R26CreER, b-actin Cre, PbCre4, PSACre, and FSPCre). All offspring developed atypical lymphoid hyperplasia, pre-neoplastic, or T-cell lymphoblasts lymphoma. Bone marrow transplantation study showed that thymic mass was developed only in K18 recipient mice with wildtype mice as donors, and no thymic mass developed in wildtype recipient mice with K18 mice as donors, suggesting K18 stroma contribute to the lymphomagenesis in these mice. |