ZIA BC 010800 (ZIA) | |||
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Title | Convection enhanced delivery of agents into the brainstem of glioma patients | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Warren, Katherine | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $30,570 | Project Dates | 01/01/2006 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Childhood Cancers (100.0%) |
Brain (100.0%) Nervous System (100.0%) |
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Research Type | |||
Technology and/or Marker Testing in a Clinical Setting Localized Therapies - Discovery and Development |
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Abstract | |||
This project is no longer accruing patients because of lack of supply of the investigational agent. We have demonstrated that the technique is relatively safe and feasible for children with the tumor, diffuse intrinsic pontine glioma. I am currently collaborating with members of NINDS and the Pediatric Brain Tumor Consortium CED committee in developing translational projects using this technique and identifying potential new agents. The ideal agent for testing is a nonneurotoxic agent with poor blood:brain barrier penetration that has demonstrated activity in vitro against CNS tumor cell lines. |