ZIABC011424 (ZIA) | |||
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Title | Bone Marrow Stromal Cells as Mitigators of Radiation Injury | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Citrin, Deborah | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $572,927 | Project Dates | 10/01/2011 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Radiation - Ionizing - Total (20.0%) Radiation - Ionizing Radiotherapy (20.0%) |
Lung (75.0%) | ||
Research Type | |||
Normal Functioning Patient Care and Survivorship Issues |
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Abstract | |||
Thus far, our studies have documented that bone marrow stromal cells are an effective mitigator of radiation injury. We have found that delivery of bone marrow stromal cells can reduce pulmonary and cutaneous fibrosis after radiation exposure. In these models our delivery system has shown an extension in survival in exposed mice with lung injury and reduction in cutaneous fibrosis. We continue to evaluate if bone marrow stromal cells can mitigate raidation dermatitis and lethal total body exposures. |