ZIA CP010212 10836 (ZIA) | |||
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Title | Associations of Anti-Parietal Cell and Anti-Intrinsic Factor Antibodies with G | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Rabkin, Charles | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $21,706 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Autoimmune Diseases (100.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Colon/Rectum (30.0%) Esophagus (35.0%) Stomach (35.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The diagnosis of autoimmune gastritis or pernicious anemia is primarily established through detection of autoantibodies directed against parietal cells (APCA) and/or intrinsic factor (AIFA), which may also be detected in some of these other autoimmune disorders. We have hypothesized that these autoantibodies may be used to detect undiagnosed autoimmune gastritis, and thus can be used as a predictive marker for gastric cancer risk. Accordingly, IIB is currently assessing these antibodies in a nested case-control study of incident gastric cancers in the Finnish Maternity Cohort. To further investigate the association of APCA and AIFA with gastric cancer risk, we propose a similar nested case-control study using fasting serum samples collected from the Alpha-Tocopherol, Beta-Carotene Cancer (ATBC) Prevention Study. The ATBC cohort provides a complementary opportunity to assess the same set of markers in both males and females from the same country. We propose the following specific aims: PRIMARY AIM 1: Autoantibody associations with gastric cancer risk ? To estimate the association of APCA and AIFA with gastric cancer risk, comparing cases and controls matched on age and date of blood draw. The magnitude of association will be calculated for gastric cancer overall, and separately for cardia and noncardia anatomic subsites. PRIMARY AIM 2: Autoantibody effect modification by H. pylori infection ? To examine the potential interaction between H. pylori seropositivity and APCA/AIFA, autoantibody associations with gastric cancer risk will be analyzed separately for H. pylori-seropositive and -negative subgroups and tested for heterogeneity. SECONDARY AIM: Autoantibody prevalence and associations with H. pylori seropositivity and other biomarkers of gastric cancer risk? To determine associations of APCA/AIFA with other biomarkers assessed in the ATBC, we will do cross-sectional analyses comparing autoantibody-positives to negatives. |