ZIA CP010144 07160 (ZIA) | |||
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Title | ITCLC Familial Testicular Cancer Projects | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Greene, Mark | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $54,759 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Testes (100.0%) | ||
Research Type | |||
Cancer-Related Biology
Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The Clinical Genetics Branch was a member of the International Testicular Cancer Linkage Consortium (""ITCLC""), a scientific collaboration dedicated to mapping and cloning the genes related to testicular cancer susceptibility in humans. This organization has ceased to function, and has been supplanted by the Testicular Cancer Consortium (""TECAC""). We contributed DNA from newly-ascertained US testicular cancer families to ITCLC testicular cancer gene discovery effort, and have continued to do so with TECAC, which is focusing on GWAS analysis of TGCT susceptibility genes. This work has led to the hypothesis that the combined effect of multiple common, low-penetrance risk alleles underlies the genetic basis of TGCT. We published a formal, quantitative analysis of the occurrence of cancers other than testicular cancer in these families, and determined that FTGCT is a site-specific syndrome: we found no excess risk of other cancers. We have published a descriptive analysis of the ITCLC testicular cancer family set (n=350), the largest collection of multiple-case families extant. The goal of this project was to identify etiologically homogenous subsets of families which might be more amenable to linkage-based gene discovery. In general, the risk factor profile of familial TGCT cases was surprisingly similar to that of sporadic TGCT. We provided the first clear proof that age-at-diagnosis of familial TGCT is significantly younger than its sporadic counterpart. We performed a centralized review of the pathology of a large series of familial testicular cancers and a comparison group of non-familial testicular cancers. This analysis is ongoing; when completed, this project will be closed. |