ZIA CP010125 - 10712 (ZIA) | |||
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Title | Ambient dioxin exposure and cancer risk in women (IWHS and AHS) | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Jones, Rena | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $100,308 | Project Dates | 09/15/2014 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (10.0%) Leukemia (20.0%) Lung (20.0%) Non Hodgkins Lymphoma (20.0%) Ovarian Cancer (10.0%) Thyroid (20.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This prospective evaluation within the population-based Iowa Women?s Health Study (IWHS) cohort will evaluate the relationship between ambient outdoor exposure to organic pollutant emissions from industrial sources and risk of multiple cancers. It builds upon the results of an exposure study nested within the NHL-SEER study, which found that local polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) emission sources contributed to residential dust levels of these compounds, and specifically relationships between indoor residential dust concentrations and facility-specific emissions for medical waste incinerators, coal-fired plants, and cement kilns. We aim to identify whether residential proximity to these facilities and/or other characteristics of exposure are associated with cancer risk among the IWHS participants. Results from the proposed study will provide insights into a limited literature on environmental dioxin exposure and cancer risk. |