ZIA CP010131-04020 (ZIA) | |||
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Title | Cancer following bone-marrow transplantation | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Curtis, Rochelle | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $552 | Project Dates | 01/01/1992 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Childhood Cancers (25.0%) Biochemical Epidemiology (45.0%) Bone Marrow Transplantation (100.0%) Cancer (100.0%) Radiation - Ionizing - Total (70.0%) Radiation - Ionizing Radiotherapy (70.0%) |
Brain (5.0%) Breast (5.0%) Buccal Cavity (5.0%) Childhood Leukemia (25.0%) Hodgkins disease (10.0%) Leukemia (25.0%) Melanoma (5.0%) Non Hodgkins Lymphoma (20.0%) Salivary Glands (5.0%) Sarcoma (10.0%) Thyroid (5.0%) |
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Research Type | |||
Systemic Therapies - Clinical Applications Surveillance |
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Abstract | |||
Although allogeneic bone marrow transplantation (BMT) is an effective treatment for leukemia and other diseases, concern about late effects of total-body irradiation and severe immune dysfunction led to the evaluation of over 30,000 BMT recipients. New findings showed that the risk of developing a non-squamous cell carcinoma after conditioning radiation was 9 times higher among patients under 30 years of age compared with non-irradiated patients, while the comparable risk for older irradiated patients was not increased. The cumulative incidence of post-transplant lymphoproliferative disorders (PTLD) after BMT was low among 21,000 patients with no major risk factors, but risk trended upwards with increasing numbers of major risk factors for PTLD. Transplantation age >50 years and second transplantation were newly identified as PTLD risk factors. |