ZID BC 011729 (ZID) | |||
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Title | Chronic graft-versus-host disease in children and young adults | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Buxbaum, Nataliya | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $8,214 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Bone Marrow Transplantation (70.0%) Cancer (100.0%) Cancer Survivorship (50.0%) Childhood Cancers (30.0%) |
Childhood Leukemia (30.0%) Leukemia (30.0%) Lung (5.0%) |
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Research Type | |||
Systemic Therapies - Clinical Applications Resources and Infrastructure Related to Cancer Control, Survivorship, and Outcomes Researc |
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Abstract | |||
I have been evaluating pediatric patients with cGVHD and providing recommendations on treatment options to their managing/referring physicians. Previously, I co-authored a book chapter on pediatric cGVHD for a patient-education book. In addition, I established a collaboration with pediatric endocrinology to further characterize frequent co-morbidities and late effects encountered in this patient population. As a result, we will shortly be submitting a manuscript for publication. Furthermore, insight gained from the bedside has provided experimental questions for my laboratory investigations, which center on chronic graft-versus-host disease. Pre-clinical models inform us on cGVHD biology by allowing evaluation of immune cells in target and lymphoid organs, which are not amenable to investigation in the clinical setting. |