Z01 CP010134-04016 (Z01) | |||
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Title | Cancer risk among Japanese A-bomb survivors | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Land, Charles | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $258,019 | Project Dates | 12/01/1979 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (30.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Helicobacter Pylori (5.0%) |
Bladder (5.0%) Brain (5.0%) Breast Cancer (10.0%) Colon/Rectum (10.0%) Esophagus (5.0%) Head and Neck (10.0%) Hodgkins disease (5.0%) Kidney Cancer (5.0%) Kidney Disease (5.0%) Liver Cancer (5.0%) Lung (5.0%) Lymphoma (5.0%) Melanoma (5.0%) Multiple Myeloma (5.0%) Non Hodgkins Lymphoma (5.0%) Ovarian Cancer (5.0%) Pancreas (5.0%) Salivary Glands (5.0%) Skin (10.0%) Stomach (5.0%) Thyroid (5.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
A cohort of 94,000 survivors of the Hiroshima and Nagasaki atomic bombings is being studied in collaboration with the Radiation Effects Research Foundation. Cohort studies are used to quantify radiation dose response and its dependence on histological subtype of tumor, age at exposure, sex, age at observation, and time following exposure. A recently completed study of salivary gland tumors found a marked excess of radiation-related tumors, largely limited to mucoepidermoid carcinoma and Warthin's tumor. Case ascertainment has been completed in studies of tumors of the breast, central nervous system, and ovary, and the data are being analyzed. Relative to age-specific baseline rates, the radiation-related excess risk of breast cancer following exposure at young ages ( |