ZIA CP010126-01202 (ZIA) | |||
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Title | Hormone-Related Cancers | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | A Brinton, Louise | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $175,771 | Project Dates | 02/01/2000 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Testes (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The incidence of testicular germ cell tumors (TGCT) has increased during the better part of the twentieth century and is of particular concern as it primarily affects young men. Though the tumor is relatively infrequent in the population as a whole, TGCT is the most common cancer among U.S. males in the age group 25-34 years. Despite the increases in TGCT rates, the etiology is still poorly understood. The only well described risk factors for TGCT are cryptorchism, family history of TGCT and personal history of TGCT. Therefore, in order to understand better the environmental and genetic determinants of TGCT risk, NCI scientists are conducting a case-control study among members of the U.S. armed forces. The study includes men who have donated a blood sample to the Department of Defense Serum Repository (DoDSR) between the years 1989 and 2002. All DoDSR donors who have developed GCT are matched to DoDSR donors who have not developed TGCT. The DoDSR serum sample will be tested for levels of organochlorines, gonadotropin levels, and viral antibody titres. In addition, each participant is donating a current buccal cell specimen that will be used in an examination of genetic susceptibility. Physical activity, medical history, medication history, and other risk factors of the participants will be analyzed in relation to TGCT association. In addition, the mothers of all participants are being invited to complete a questionnaire concerning a variety of possible risk factors such as physical activity, medical history, medication history, perinatal exposures and other risk factors. The mothers are also be asked to donate a buccal cell specimen. As of November, 2004, the study had enrolled 736 cases, 838 controls and 1048 mothers of the case and control men. The study is scheduled to cease field activities in February, 2005. |