ZIA CP010218-01150 (ZIA) | |||
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Title | Biliary tract cancer case-control study in Shanghai | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Koshiol, Jill | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $55,344 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (10.0%) Basic Behavioral and Social Science (100.0%) Behavioral and Social Science (100.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Diabetes (10.0%) Digestive Diseases (100.0%) Inflammatory Bowel Disease (10.0%) |
Gallbladder (50.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"""The key aims of this study include estimation of possible risks associated with a history of gallstones, bacterial infection of the biliary tract, other medical history, diet, use of tobacco and alcohol, obesity, reproductive factors, and family history of cancer. Information will be used to examine risk patterns a) separately by anatomic subsite; b) among patients with gallbladder cancer vs. controls undergoing cholecystectomy for gallstones; c) among the patients with bile duct cancer vs. hospital controls without cancer who undergo surgery for removal of bile duct stones. We will also attempt to ascertain reasons for the rising incidence of biliary tract cancers in Shanghai. Serum collected from all subjects will be analyzed for estrogens and other hormones, vitamins C and E, cholesterol, and bacterial antibodies (including salmonella typhi, paratyphi, and escherischia coli). Bile fluid will be cultured for aerobic bacteria, and gallstones analyzed for color, cholesterol, and evidence of bacteria function. A major challenge in biliary tract cancer research is to determine how cancer risk factors differ from those for gallstone or biliary duct stone disease, since many people have gallstones (or biliary duct stones) but few develop cancer.""" |