ZIA BC 010763 (ZIA) | |||
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Title | Building on the success of the adoptive immunotherapy of cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Restifo, Nicholas | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $3,493,116 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (30.0%) Autoimmune Diseases (10.0%) Bioengineering (50.0%) Cancer (100.0%) Digestive Diseases (10.0%) Gene Therapy (25.0%) Gene Therapy Clinical Trials (25.0%) Interferon (20.0%) Surgery (20.0%) |
Brain (10.0%) Breast (5.0%) Colon/Rectum (5.0%) Esophagus (5.0%) Hodgkins disease (5.0%) Kidney Disease (10.0%) Lung (5.0%) Melanoma (15.0%) Nervous System (10.0%) Non Hodgkins Lymphoma (5.0%) Ovarian Cancer (10.0%) Pancreas (5.0%) Prostate (10.0%) Sarcoma (10.0%) Urinary System (10.0%) Kidney Cancer (10.0%) |
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Research Type | |||
Systemic Therapies - Clinical Applications Resources and Infrastructure Related to Treatment and the Prevention of Recurrence |
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Abstract | |||
Adoptive immunotherapy for cancer: building on success. Substantial progress has been made in our understanding of the molecular and cellular bases of T cell mediated anti-tumor responses. T cells are potent effectors of the adaptive anti-tumor immune response. Some target antigens recognized by tumor-reactive CD8+ T cells are mutated antigens. The molecular signals that modulate T cell activation, function and memory are being elucidated. Both positive and negative signals from co-stimulatory molecules have been shown to shape the anti-tumor response. Cytokines, including those with receptors that contain the common cytokine-receptor gamma chain have been shown to alter the programming of effector CD8+ T cells. We are also characterizing the metabolic characteristics of T cells that are capable of destroying tumor. In addition, we have studied the mechanisms that tumor cells use to escape recognition by T cells. |