ZIA CP010126-01047 (ZIA) | |||
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Title | Breast cancer study of genetic susceptibility and environmental factors | ||
Institution | NCI, Bethesda, Ma | ||
Principal Investigator | Figueroa, Jonine | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $29,230 | Project Dates | 02/01/1998 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (10.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
The main goal of this study is to evaluate genetic determinates of breast cancer risk and their interactions with environmental risk factors. To accomplish this goal, we have collected buccal cell specimens from women participating in the Collaborative Breast Cancer Study, and extramurally-funded population based case-control study of breast cancer in the statees of Wisconsin, Massachusetts and New Hampshire. The CBCS obtained risk factor information from cases of invasive and in-situ breast cancer and from population controls through a telephone interview. At the end of the interview, women were invited to participate in the buccal cell component of the study. We are currently evaluating polymorphisms in genes involved in candidate pathways, novel loci discovered in GWAS and gene-gene/gene-environment interactions. |