ZIA CP010195 03031 (ZIA) | |||
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Title | ATBC Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Albanes, Demetrius | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $853,810 | Project Dates | 02/01/2002 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (5.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (5.0%) Chemoprevention (20.0%) Digestive Diseases (5.0%) |
Bladder (7.0%) Brain (3.0%) Colon/Rectum (11.0%) Esophagus (3.0%) Kidney Cancer (6.0%) Kidney Disease (6.0%) Larynx (3.0%) Leukemia (3.0%) Liver Cancer (4.0%) Lung (10.0%) Non Hodgkins Lymphoma (11.0%) Pancreas (13.0%) Prostate (23.0%) Stomach (2.0%) Testes (1.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
The ATBC Study, a project between Finlandıs National Public Health Institute (NPHI) and NCI, was conducted to determine whether daily supplementation with a-tocopherol, b-carotene, or both, would reduce the incidence of lung or other cancers. Male smokers between the ages of 50 and 69 were recruited from southwestern Finland between April 1985 and June 1988. A total of 29,133 men were randomly assigned to one of four intervention groups: 50 mg/day a-tocopherol (as dl-a-tocopheryl acetate); 20 mg/day b-carotene; both a-tocopherol and b-carotene; or placebo. They were followed for five to eight years during the trial, until death, or 30 April 1993 when intervention was stopped (median follow-up, 6.1 years). Follow-up for endpoints was continued postintervention. |