ZIA CP010126-01048 (Z1A) | |||
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Title | Collaborative Perinatal Project | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | McGlynn, Katherine | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $301 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Down Syndrome (20.0%) |
Testes (100.0%) | ||
Research Type | |||
Cancer-Related Biology
Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Cryptorchism is strongly associated with the development of testicular germ cell tumors (TGCT), possibly because of a common etiology. However, while TGCT incidence varies greatly between white and black men, little variability has been reported between the groups in cryptorchism incidence. This may suggest that cryptorchism risk factors differ by ethnicity. To examine this hypothesis, a study was conducted among participants of the Collaborative Perinatal Project. The analysis found that while the cryptorchism rate was significantly higher among white babies (1.90% vs. 1.55%), the difference was incompatible with the five-fold difference in TGCT rates. The principal maternal risk factors among white babies were age (p=0.03), hypertension/proteinuria (p=0.006) and length of time to become pregnant (p=0.055), while major maternal risk factors among black babies were age (p=0.06), height (p=0.007), weight (p=0.06) and radiation exposure (p=0.02). Only height, however, had a different relationship to risk among black and white babies. Neonatal associations with risk (shorter gestational age, lower birthweight, shorter length) were similar in the two groups. These results do not support the hypothesis that the risk factors for cryptorchism vary by ethnicity, but may suggest that cryptorchism is not as closely linked to TGCT among black men as white men." |