ZIA CP010131-10782 (ZIA) | |||
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Title | Genomics of multiple primary tumors | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Morton, Lindsay | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $214,814 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (100.0%) Childhood Cancers (75.0%) |
Breast (10.0%) Eye (10.0%) Hodgkins disease (10.0%) Stomach (15.0%) Thyroid (15.0%) Sarcoma (30.0%) |
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Research Type | |||
Cancer Initiation: Oncogenes & Tumor Suppressor Genes Patient Care and Survivorship Issues |
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Abstract | |||
"""Second cancers are a leading cause of morbidity and mortality among cancer survivors. Childhood cancer survivors are particularly vulnerable to the induction of second cancers associated with radiotherapy and cytotoxic chemotherapies used in first primary cancer treatment. Although ionizing radiation and alkylating agent-based chemotherapy are known carcinogens, the biologic mechanisms underlying the carcinogenic processes are unknown. Recent advances in technologies for characterizing the mutational spectrum in archival tumor tissues coincide with the maturation of several long-term follow-up studies of cancer survivors with detailed data on treatment exposures, providing a unique opportunity to discover the biologic basis of treatment-induced second cancers. We will conduct molecular studies on paired archival tumor specimens and germline DNA in cancer survivors who have developed a second cancer. """ |