ZIA CP010226 10686 (ZIA) | |||
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Title | Cancer and Health Outcomes Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hoover, Robert | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $323,191 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (100.0%) Diabetes (50.0%) Metastasis (100.0%) |
N/A | ||
Research Type | |||
Resources and Infrastructure Related to Etiology Resources and Infrastructure Related to Detection, Diagnosis, or Prognosis |
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Abstract | |||
Our overarching objective is to build a new prospective multi-center adult cohort study set in Kaiser Permanente (KP) with rich exposure information and accurate outcome information that will be used as a division-wide resource to investigate novel hypotheses about the etiology of cancer by combining questionnaire data, medical records, tumor tissue and serial biospecimens. Given the large-scale nature of the planned cohort study, we propose to conduct a feasibility study in KP Colorado, one of the sites identified for the HMO cohort study. In the feasibility study, we will invite 1000 eligible members of KP Colorado to participate in the study. We will randomly assign 500 to be invited by mail and the consent and questionnaire will be included with the invitation. The other 500 will be invited by email and if they agree to participate they will then be mailed the consent documents and a questionnaire.. All participants will be asked to provide a blood specimen at their local Kaiser clinic within three months of enrolling in the study. We will evaluate the following outcomes: the % enrollment, % questionnaire completion, % agreement to blood draw, % completion of blood draws, the time between enrollment and blood draw and compare the available characteristics of the participants and the non-participants. These measures along with existing feasibility data from previous successful collaborations between Kaiser and DCEG will provide important information for planning of a larger scale pilot and eventually a full cohort study. |