Z01 CP004410-08285 (Z01) | |||
---|---|---|---|
Title | Families at high risk of cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Tucker, Margaret | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $300,416 | Project Dates | 01/01/1965 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (50.0%) Cancer (100.0%) Childhood Cancers (20.0%) Neurofibromatosis (7.0%) |
Bladder (10.0%) Brain (10.0%) Eye (10.0%) Head and Neck (5.0%) Kidney Cancer (10.0%) Kidney Disease (10.0%) Lung (10.0%) Pharynx (5.0%) Prostate (10.0%) Skin (10.0%) Stomach (5.0%) |
||
Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
|||
Abstract | |||
Investigations of families and individuals at high risk of cancer often lead to etiologic clues that may be important in the general population. Families with multiple members who have an unusual pattern or number of cancers are evaluated clinically and risk factor information is obtained. When specific genetic alterations or host characteristics predicting risk are identified, population studies are conducted to assess these factors outside of high-risk families. Studies of individuals at high risk because of specific exposures (i.e., radiation or chemotherapy) also yield important information about cancer causation. Most of these investigations have clinical, epidemiologic, and molecular components. |