ZIA CP000185-10575 (ZIA) | |||
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Title | A Study of the Prevalence of Esophageal Squamous Dysplasia in Western Kenya: the | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Dawsey, Sandy | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $133,174 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Digestive Diseases (100.0%) |
Esophagus (100.0%) | ||
Research Type | |||
Resources and Infrastructure Related to Prevention Resources and Infrastructure Related to Detection, Diagnosis, or Prognosis |
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Abstract | |||
"Esophageal squamous cell carcinoma (ESCC) is common in the developing world, and is a leading cancer diagnosis in western Kenya. Tenwek Hospital is a 300 bed mission hospital located in Bomet District, Rift Valley Province, Kenya, approximately 200 miles northwest of Nairobi. Tenwek serves as a primary health care facility for approximately 400,000 people within a 50 km radius of the hospital. ESCC is the most common malignancy seen at Tenwek Hospital, and the patients show a very unusual age distribution, with about 8% of cases diagnosed at </= 30 years of age. Our long-term goal is to understand the risk factors and pathogenesis of ESCC in western Kenya, and to establish effective screening and prevention programs there. We hypothesize that esophageal squamous dysplasia (ESD), the precursor lesion of ESSC, is common in asymptomatic adults in this area, and the current protocol is designed to determine the prevalence of and risk factors for ESD in this population. The specific aims of this study are: (1) To determine the prevalence of esophageal squamous dysplasia in adult residents of western Kenya; and (2) To identify risk factors for ESD. To accomplish these objectives, 300 asymptomatic adult residents of villages within 50 km of Tenwek Hospital will complete a risk factor questionnaire, give blood and urine samples, and undergo transoral videoendoscopy of the esophagus with iodine chromoendoscopy and mapping and biopsy of identified lesions. This protocol will determine, with reasonable precision, the prevalence of ESD in these asymptomatic residents and will explore risk factors for ESD. Results will guide the design of subsequent programs for screening and endoscopic treatment of ESD, and will enable comparison of risk factors for ESD and invasive ESCC in the same population. Progress: Accrual of the 300 subjects has been completed. 14% of the subjects had ESD, including 3% with high-grade ESD. Additional data analysis is ongoing." |