ZIA CP010169 03030 (ZIA) | |||
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Title | Breast cancer in Asian-American women | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Ziegler, Regina | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $274,191 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
International variation in breast cancer rates and migrant studies indicate that modifiable factors play a major role in breast cancer etiology, although the specific lifestyles and environmental exposures remain elusive. We designed a large case-control study of breast cancer in Asian-American women to take advantage of their diversity in diet, lifestyle, and breast cancer risk. Childhood, adolescent, and adult exposures were assessed by interviewing both study participants and their mothers. To complement the extensive interview information, body size and shape were measured, and blood and urine samples were collected. Micronutrients, fatty acids, lipids, hormones, growth factors, estrogen metabolites, and phytoestrogens are being measured in these specimens. We found a six-fold gradient in breast cancer risk by migration history within our study population. |