ZIA CP004410-08085 (ZIA) | |||
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Title | Chordoma Families | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Yang, Rose | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $53,760 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Brain (10.0%) Central Nervous System - Not Including Brain (70.0%) Head and Neck (20.0%) Pharynx (15.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
"""The purpose of this study is to try to identify a gene or genes involved in the development of chordoma, a rare primary bone tumor. Families with two or more blood relatives with chordoma or with one blood relative with chordoma and another blood relative with a primary brain tumor are eligible to participate in it. The individuals with the tumors and selected relatives are brought to the NIH Clinical Center to participate in clinical studies. This includes providing personal and family medical history information, undergoing a physical examination and Magnetic Resonance imaging of the neuroaxis (brain and spinal cord), and providing a blood sample or cheek cells as a source of DNA. Participants provide permission to obtain past medical records pertaining to chordoma and other cancers or related illnesses and a piece of tumor stored after any cancer surgery. DNA is used in a variety of laboratory studies aimed at identifying genes involved in chordoma development. This study began in 1996." |