ZIA CP010134-04016 (ZIA) | |||
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Title | Cancer risk among Japanese A-bomb survivors | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Mabuchi, Kiyohiko | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $95,441 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (50.0%) Autoimmune Diseases (20.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"""A cohort of 94,000 survivors of the Hiroshima and Nagasaki atomic bombings is being studied in collaboration with the Radiation Effects Research Foundation. Cohort studies are used to quantify radiation dose response and its dependence on histological subtype of tumor, age at exposure, sex, age at observation, and time following exposure. Following two landmark publications of comprehensive analyses of LSS solid cancer incidence data, the third analyses in undeway of solid cancer incidence data updated through 2009, adding eleven years of follow up. The latest analyses will generate a series of all-site and organ specific reports. The first report on all solid cancer incidence has been pusblished, demonstrating that solid cancer risks remain elevated more than 60 years after exposure and the presence of upward curvature in the dose response independent of adjustment for smoking. Another published report on respiratory cancer shows a signficant linear dose respose for lunng cancer with no evidence of curvature, and a significantly higher radiation risk for low-to-moderate smokers than for heavy smokers, with little evidence of excess risk in heavy smokers. There was little evidnce of a radiation effect on laryngeal cancer. """ |