ZIA CP010176-10076 (ZIA) | |||
---|---|---|---|
Title | KSHV/HHV8 in sickle cell and other Ugandan populations | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Mbulaiteye | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $32,969 | Project Dates | 03/24/2004 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Behavioral and Social Science (50.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Herpes - Genital (20.0%) |
Kaposi Sarcoma (80.0%) Sarcoma (80.0%) Sarcoma, Soft (Sarcoma Subset) (80.0%) |
||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
|||
Abstract | |||
Transmission of KSHV/HHV8 to Ugandan children with sickle cell disease. The Branch enrolled 600 children attending the sickle cell clinic in Kampala, Uganda, finding that the KSHV/HHV8 infection was associated with blood transfusion (2.6% risk per unit transfused), low maternal socio-economic status, use of surface water, and a high density, rural household. HHV8 PCR testing of saliva and blood lymphocytes showed high frequency and levels of viral shedding. Shedding in saliva was associated with shedding in peripheral blood, in both fluids was associated with younger age and with drinking water from unclean surface water sources. To obtain better support for the role of parasites, Th1/Th2 ummune deregulation, ~3,300 individuals from a nationally representative sample of individuals surveyed to participate in a sero-behavioral survey in Uganda will be tested for HHV8 serology and viral shedding. The survey has rich demographic (Household and Individual questionnaire data) and laboratory (HIV, syphilis, HSV2, and HBV) data. The HHV8 serology study will: a) estimate HHV-8 seroprevalence in Uganda, a country where pre-AIDS KS is well described; b) examine the association of sexually transmitted diseases (STDs), HIV status and HHV-8 seroprevalence; and c) confirm previous findings where we showed an association between HHV-8 serostatus a, socioeconomic factors and water source. The HHV8 PCR study will estimate HHV8 viral carriage by geography in Uganda, a country where pre-AIDS KS is well described; b) examine the association of sexually transmitted diseases (STDs), HIV status and HHV8 viral carriage; and c) examine whether viral carriage is associated socioeconomic factors and water source, a marker of exposure to soil and water-related parasites, and presumably skewing to Th2-type immune response. Together, these studies will clarify the role of environment, behavior in HHV8 and KS epidemiology. |