ZIA CP010120-02053 (ZIA) | |||
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Title | Central and Eastern Europe kidney cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Purdue, Mark | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $92,852 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (20.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Kidney Cancer (100.0%) Kidney Disease (100.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
"""A hospital-based case-control study of kidney cancer was conducted to evaluate occupational and other risk factors in six centers (Moscow, Russia; Bucharest, Romania; Lodz, Poland; Brno, Central Moravia; and Prague, Czech Republic) across central and eastern Europe. The study areas have demonstrated a wide range of incidence rates for kidney cancer, including the world's highest rates in the Central Moravia region. In-person interviews were conducted to elicit information on demographic background, smoking and passive smoke exposure, alcohol drinking, dietary practices, height, weight and medical history, family history of cancer, residential history, and occupational history. Medical records were extracted for case diagnostic information. We have explored variation in genes that play a general role in carcinogenesis, cancer susceptibility, and have collaborated on genome wide assacion studies of kidney cancer. We have analyzed tumor samples for mutations in important tumor suppressor genes and have conducted protein expression studies using tissue micrarrays. These markers have been evaluated for associations with patient/tumor characteristics, risk factors and exposures. They are now being evaluated for association with survival under CAS 19420.""" |