ZIA CP010145 07040 (ZIA) | |||
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Title | Breast imaging studies in women at high genetic risk of breast cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Loud, Jennifer | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $407,935 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (25.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Chemoprevention (50.0%) Behavioral and Social Science (25.0%) |
Breast (85.0%) Ovarian Cancer (15.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interventions to Prevent Cancer: Personal Behaviors (Non-Dietary) that Affect Cancer Risk |
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Abstract | |||
The Breast Imaging Study enrolled 200 women with, or at high risk of carrying, a germline <i>BRCA1/2</i> mutation, in a 4-year prospective cohort study. Each participant underwent annual mammography, breast MRI, breast duct lavage (BDL), serum CA-125 and transvaginal ultrasound. Changes in mammographic density and MRI fibroglandular volume were evaluated, known breast cancer risk factors and medical/ lifestyle decisions were correlated with various outcomes. We studied breast duct lavage as potential clinical and research tool, and found it unsatisfactory.The study has evaluated the psychosocial impact of being a member of a <i>BRCA</i>-positive family, leading to multiple publications on intra-family communications, the experience of being mutation-negative within a <i>BRCA</i>-positive family, the tolerability of new breast cancer screening techniques, perceptions of risk and worry among <i>BRCA1/2</i> mutation carriers and their impact on decision- making related to risk-reducing surgery, and the impact of being a mutation carrier on the life-course of very young women,. We have reported on the lack of mammographic density differences between mutation carriers and non-carriers, and the two-fold increase in risk of being a mutation carrier among women with abnormalities in mammographic texture. We continue to collaborate with investigators at the University of Chicago to evaluate novel digitized mammogram and MRI imaging features as predictors of breast cancer risk. In addition, the study provides biospecimens for research collaborations within the Consortium of Investigators of Modifiers of BRCA. In the past year, we have reported on the detection of and correlation between estrogen metabolites in breast duct lavage, nipple aspirate fluid and serum. This study is clinically inactive. Research activities are focused on leveraging the biospecimens and data from study participants in new laboratory-based translational research projects. |