ZIA CP000185-10796 (ZIA) | |||
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Title | AfrECC Consortium GWAS | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Dawsey, Sandy | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $111,246 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Digestive Diseases (10.0%) |
Esophagus (100.0%) | ||
Research Type | |||
Cancer Initiation: Oncogenes & Tumor Suppressor Genes Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"Esophageal squamous cell carcinoma (ESCC) is an important and understudied cause of cancer death. ESCC has a very uneven distribution and there are several regions of the world with very high incidence rates including China, Iran and countries in eastern and southern Africa. The African Esophageal Cancer Consortium (AfrECC) is currently conducting research on the etiology of ESCC in Kenya, Tanzania, Zambia, South Africa and Malawi. The most valid and efficient method of assessing the role of common genetic variants in the etiology of cancer is to perform a Genome Wide Association Study (GWAS), which examines genetics variants across the entire genome in a single study. Generally, large sample sizes (2000 cases and 2000 controls or more) are critical to ensure valid results. We would like to collect at least 2000 ESCC cases and 2000 esophageal cancer-free controls from each geographic sub-region (1. Kenya and Tanzania; 2. Zambia and Malawi and 3. South Africa). Control selection for GWAS is relatively flexible as long as it is conducted within the same population as the cases. Each case and control will be asked to provide a DNA sample for genetic analysis. Blood samples are acceptable if they have been collected as part of a separate project, but in many instances a saliva collection will be simpler. DCEG/NCI will provide room-temperature stable saliva DNA collection kits. For the primary analysis of GWAS we only require minimal information from subjects. DCEG/NCI will provide a brief (1 page) questionnaire to be administered to subjects in order to collect information on age, sex, self-reported ethnic group, family history of esophageal cancer, and past and current use of tobacco and alcohol. For cases, we would also like to know how the ESCC diagnosis was made (e.g. clinical diagnosis, X-ray, endoscopic visualization of tumors, or histologic confirmation). All diagnostic methods will be acceptable. " |