ZIA CP010150 - 10362 (ZIA) | |||
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Title | Cancer risk in solid organ transplant recipients and endstage renal disease | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Engels, Eric | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $414,657 | Project Dates | 06/01/2006 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Organ Transplantation Research (50.0%) |
Cervical Cancer (5.0%) Head and Neck (5.0%) Hodgkins disease (10.0%) Kaposi Sarcoma (10.0%) Kidney Cancer (10.0%) Kidney Disease (10.0%) Liver Cancer (10.0%) Lung (10.0%) Multiple Myeloma (10.0%) Non Hodgkins Lymphoma (30.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Resources and Infrastructure Related to Etiology |
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Abstract | |||
Solid organ transplantation provides life-saving treatment for end-stage organ disease but is associated with substantially elevated cancer risk, largely due to the need to maintain long-term immunosuppression. End-stage renal disease (ESRD), the most common type of end-stage organ disease leading to transplant, is itself linked to increased risk for some cancers. Despite previous research, important research questions remain concerning the role of immunosuppression and other factors in causing cancer in this setting. The investigators hace linked databases of U.S. transplant recipients (362,288 transplants 1987-2005), donors, and wait list candidates, and to multiple U.S. cancer registries. This linkage will allow identification of incident cancers in transplant recipients. Using these data, investigators will conduct a detailed evaluation of the spectrum of cancer risk in transplant recipients and ESRD patients. Additionally, the investigators will examine cancer risk in transplant recipients in relation to whether donors themselves had cancer, to study possible donor-to-recipient transmission of cancer. The investigators will also study whether proposed cancer risk factors ( e.g., underlying medical condition, infection with oncogenic viruses, immunosuppressive medications), documented in transplant and ESRD files, are associated with increased risk of particular types of cancer. " |