ZIA CP000101 10336 (ZIA) | |||
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Title | Postmenopausal women's alcohol study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Abnet, Christian | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $951 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (25.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (75.0%) Colon/Rectum (20.0%) Esophagus (5.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Dietary Interventions to Reduce Cancer Risk and Nutritional Science in Cancer Prevention |
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Abstract | |||
The main goal of this study is to attempt to elucidate metabolic mechanisms through which alcohol consumption might act as a risk factor for breast cancer. Studies to date examining hormonal effects of alcohol consumption have been primarily in alcoholics, where it is difficult to distinguish specific effects of alcohol from generalized liver damage, or studies involving administration of acute large doses of alcohol followed by a short period of observation and sampling. Only one previous study has involved long term ingestion under controlled dietary circumstances, and that was in premenopausal women. We propose here to explore biological mechanisms by which alcohol may be involved in mammary carcinogenesis in postmenopausal women by conducting a controlled dietary study of low to moderate alcohol use. Sixty healthy postmenopausal women not taking estrogen replacement therapy will each receive 3 different 8-week controlled diet period alcohol treatments in random order: 0 gm alcohol, 15 gm alcohol, and 30 gm alcohol. Biologic samples will be collected during the final week of each controlled period and assayed to determine the effect of alcohol consumption on serum and urine hormone levels. Alcohol has many other biologic effects beyond its potential impact on hormones and breast cancer. Most importantly, moderate alcohol intake is associated with a reduced risk of cardiovascular disease, the leading cause of mortality in women in the U.S. Recommendations regarding the use or avoidance of alcohol, therefore, must consider both its potential benefit on cardiovascular disease as well as its potential risk for breast cancer. The proposed study will consider other biologic parameters potentially influenced by alcohol by evaluating the effects of alcohol consumption on lipid levels, oxidative stress, and micronutrient levels as well as genetic polymorphisms related to alcohol and hormone metabolism that may affect hormone levels. |