Z01 CP010128-01220 (Z01) | |||
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Title | Breast implant follow-up study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Brinton, Louise | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $31,576 | Project Dates | 10/01/1992 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast Cancer (50.0%) Central Nervous System - Not Including Brain (15.0%) Lung (15.0%) Lymphoma (5.0%) Multiple Myeloma (5.0%) Non Hodgkins Lymphoma (5.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interventions to Prevent Cancer: Personal Behaviors That Affect Cancer Risk |
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Abstract | |||
A retrospective cohort study has been conducted of 13,488 women receiving cosmetic implants and 3,936 patients who had other types of plastic surgery at 18 plastic surgery practices during the period 1960-1988. Patients have been traced through 1997 and asked to complete a detailed questionnaire. Attempts have been made to verify self-reports of cancer through retrieval of medical records. Subjects have also been traced with respect to causes of death. A number of analyses of the collected data have been completed. Women with breast implants were not found to have an unusual risk of breast cancer, but initially there were increased risks found for cervical, vulvar, respiratory and brain cancers. Although the cervical and vulvar cancer excesses might be attributable to lifestyle factors, reasons for the elevated risks of the other sites were less apparent. Mortality analyses also documented excess risks of suicides among women with breast implants. Most recently, the mortality data have been updated. Although the risk of suicide among implant patients persisted, there were no additional brain cancer deaths observed, raising questions as to the biologic reality of the previously observed excess risk. In addition, the risk of death from lung cancers did not show a dose response relationship with time, also leading to questions regarding a biologic connection. Analyses have also been completed with respect to the risk of connective tissue disorders among women with breast implants. This highlighted the difficulties of assessing relationships with these conditions when self reports are involved. However, it was clear that if there were elevated risks that they were considerably less than had been proposed on the basis of uncontrolled clinical studies. |