Z01 CP010131-04021 (Z01) | |||
---|---|---|---|
Title | Cancer following radiotherapy for benign gynecologic disorders | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Ron, Elaine | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $3,528 | Project Dates | 11/01/1983 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Bladder (6.0%) Breast Cancer (6.0%) Cervical Cancer (6.0%) Colon/Rectum (13.0%) Hodgkins disease (6.0%) Kidney Cancer (6.0%) Kidney Disease (6.0%) Leukemia (12.0%) Lymphoma (7.0%) Multiple Myeloma (6.0%) Non Hodgkins Lymphoma (7.0%) Ovarian Cancer (7.0%) Pancreas (6.0%) Stomach (7.0%) Uterine (6.0%) |
||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
|||
Abstract | |||
Cancer incidence is being evaluated in a multi-center retrospective cohort study of nearly 13,000 women who had been treated with radiation for benign gynecologic disorders between 1925 and 1966. Analyses to date have revealed excesses of acute and myelocytic leukemias but no increase in chronic lymphocytic leukemia or other hematopoietic cancers. The excess leukemia risk was the same as for women irradiated for cancer of the uterine cervix or corpus, despite substantially lower average radiation doses to bone marrow as for women treated for malignant disease. This most likely is due to the killing of potentially leukemic stem cells in the most highly irradiated parts of the bone marrow. Radiation dose-response relationships also were seen for cancers of the bladder, colon and ovary but not for cancers of the uterus or rectum, which appear to be radio-resistant organs. |