ZIA CP010212 10835 (ZIA) | |||
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Title | Immune-related conditions and risk of gastric cancer in elderly U.S. population | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Rabkin, Charles | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $10,853 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Autoimmune Diseases (100.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Colon/Rectum (30.0%) Esophagus (35.0%) Stomach (35.0%) |
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Research Type | |||
Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors Surveillance |
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Abstract | |||
We will conduct a population-based case-control study using the SEER-Medicare linked database. The primary aim of this study is to determine the spectrum and population impact of immune-related conditions associated with risk of gastric cancer overall and by anatomical subsite. Secondary aim is to determine the spectrum of immune-related and autoimmune conditions associated with pernicious anemia, the most severe manifestation of autoimmune gastritis. Although the etiology of autoimmune gastritis is unclear, we suspect that it results from a constellation of autoimmune phenomena. Many other autoimmune diseases are reported to be associated with autoimmune gastritis, including autoimmune thyroiditis, type I diabetes, vitiligo, and Addison disease. Pernicious anemia, which is an aggravated progression of autoimmune gastritis, has also been described in patients with specific immune-related conditions that include IgA deficiency, chromosome 18q deletion syndrome and X-linked hypogammaglobulinaemia, Good syndrome and common variable immunodeficiency Recently, a divergent trend in gastric cancer incidence has been observed in several parts of the world. In spite of decreasing in incidence in most age groups, young generations, especially females have shown an increase in incidence. We have confirmed this pattern in a recent analysis using National Cancer Institute?s Surveillance Epidemiology and End Results (SEER) and North America Association of Central Cancer Registries (NAACCR) data (JNCI, in press). Increases were largely limited to non-Hispanic whites, and in counties with less than 20% prevalence of poverty, suggesting factors other than H. pylori may be driving the trends. The increase was especially prominent in non-Hispanic white females < 50 years of age for corpus gastric cancer. |