ZIA BC 011478 (ZIA) | |||
---|---|---|---|
Title | Tumor infiltrating lymphocyte therapy for human papillomavirus-positive cancers | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hinrichs, Christian | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $162,606 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2013 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Digestive Diseases (21.0%) |
Pharynx (27.0%) Anus (21.0%) Cervical Cancer (48.0%) Penis (2.0%) Vaginal (2.0%) |
||
Research Type | |||
Systemic Therapies - Clinical Applications | |||
Abstract | |||
The purpose of this project is to determine the objective clinical response rate of TIL therapy in HPV-positive cancers and to investigate the specificity, phenotype, and function of TIL from HPV-positive cancers in vitro and in vivo. Our laboratory has established the feasibility of generating TIL from HPV-positive cancers at clinical grade and scale. Based on that work we have initiated a clinical trial of TIL from HPV-positive cancers (HPV-TIL) with the primary end point of objective clinical response rate. The trial is open to accrual at this time. Laboratory studies to characterize HPV-TIL and to innovate the next generate of cellular therapies for this family of diseases are ongoing. |