ZIA CP010133-04180 (ZIA) | |||
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Title | Cancer and Other Mortality Risks in a Cohort of U.S. Radiologic Technologists | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Linet, Martha | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $840,500 | Project Dates | 09/01/1982 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Radiation - Ionizing - Total (100.0%) Radiation - Ionizing Low Level (100.0%) Radiation - Non Ionizing - Total (25.0%) |
Brain (5.0%) Breast (40.0%) Eye (2.0%) Heart (2.0%) Hodgkins disease (2.0%) Leukemia (15.0%) Lung (5.0%) Melanoma (5.0%) Multiple Myeloma (2.0%) Non Hodgkins Lymphoma (2.0%) Thyroid (15.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
In 1982, the REB, initiated a nationwide cohort study of all cancer incidence and mortality among 146,022 U. S. radiologic technologists. The cohort with 73% females, and very high response rates offers a rare opportunity to study effects of occupational protracted low- to moderate-dose radiation exposure on breast and thyroid cancer, the two most sensitive organ sites for radiation carcinogenesis in women. All other cancer and non-cancer serious disease outcomes are also being evaluated in relation to protracted low-to-moderate dose exposures. Presently we are expanding the scope of the study to include a number of cancers in relation to occupational and personal exposure to ionizing radiation, as well as studies of skin cancers in relation to radiation exposure and levels of UVR exposure. During the past year, efforts were completed to medically-validate skin and other cancers reported on the third survey and to collect buccal cell samples from subjects who declined to provide a venipuncture blood sample. Three fourth survey questionnaire modules (core questions, work history with interventional radiation procedures, work history with radioisotope procedures) were developed and pre-tested. The study website was overhauled, cohort vital status and addresses were updated, and a 2012 newsletter was mailed to approximately 93,000 living study participants. The fourth survey core questionnaire will be administered during 2012-2013. A major enhancement to the occupational radiation dosimetry system was completed, providing estimated badge and organ doses for each study participant for each year worked as a radiologic technologist from 1903 through 1997. Cancer radiation dose-response risk analyses will be completed during the coming year. |