ZIA CP010131 10740 (ZIA) | |||
---|---|---|---|
Title | CCSS - Breast cancer risk after childhood cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Berrington, Amy | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $61,503 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (50.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Cancer Survivorship (100.0%) Chemotherapy (50.0%) Behavioral and Social Science (50.0%) Childhood Cancers (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
|||
Abstract | |||
Previous studies have demonstrated a markedly increased risk of breast cancer following radiotherapy to the chest at a young age, with excess risk persisting for more than 25 years. Data are consistent with a linear dose-response relation for breast doses up to 40 Gy. A recent report from the Childhood Cancer Survivor Study (CCSS) indicated an 11-fold increased risk at 40 Gy relative to zero dose. The estimated cumulative absolute risk of breast cancer for a female treated with =40 Gy of chest irradiation for Hodgkin lymphoma at age 25 years is 29% by age 55 years. Less clear are factors that may modify the dose-response relation. Particularly as the survivors mature into middle age and postmenopausal years when breast cancer incidence rates are expected to increase, it is important to understand whether radiation-related risks add to, or multiply, risk associated with other established breast cancer risk factors (e.g., reproductive and hormonal factors, family history of breast cancer) and to understand the temporal patterns of these radiation-induced breast tumors. A case-control study is being conducted within the CCSS to investigate modifiers of the radiation dose-response relation. |