ZIA CP010212 - 10401 (ZIA) | |||
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Title | Human Papillomavirus, HIV, and Penile Cancer Precursors in the Rakai Circumcisio | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Rabkin, Charles | NCI Program Director | Mell |
Cancer Activity | Division | DCEG | |
Funded Amount | $460 | Project Dates | 01/14/2007 - 00/00/0000 |
Fiscal Year | 2015 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Urinary System (100.0%) | ||
Research Type | |||
Combinations of Localized and Systemic Therapies Surveillance |
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Abstract | |||
Endemic hepatitis B virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in Sub-Saharan Africa, where most HBV infections occur through horizontal transmission in childhood (e.g. parenteral exposure), and through sexual contact in adolescence and early adulthood. Male circumcision (MC) has been shown to decrease risk of human immunodeficiency virus (HIV), human papillomavirus (HPV), and herpes simplex virus type-2 (HSV-2) infections. IIB is therefore investigating whether MC had a protective effect against HBV sexual acquisition in a previously conducted randomized trial. Baseline sera samples from all participants who were (n= 1,391) or were not circumcised (n=1,393) will be compared for serologic evidence of incident HBV infection using sera collected at enrollment and semiannually for 3.5 years. |