Z01 CP010120-02053 (Z01) | |||
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Title | Central and Eastern Europe kidney cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hayes, Richard | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $90,899 | Project Dates | 09/01/2000 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (20.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Kidney Cancer (100.0%) Kidney Disease (100.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
A hospital-based case-control study of kidney cancer is proposed to evaluate occupational and other risk factors in six centers (Moscow, Russia; Bucharest, Romania; Lodz, Poland; Brno, Central Moravia; and Prague, Czech Republic) across the central and eastern Europe. The study areas have a wide range of incidence rates for kidney cancer, including the world's highest incidence rates in the Central Moravia region. In-person interviews will be conducted to elicit information on demographic background, smoking and passive smoke exposure, alcohol drinking, dietary practices, height, weight and medical history, family history of cancer, residential history, and occupational history. Medical records will be extracted for case diagnostic information. We will also explore varieants in genes that may play a general role in carcinogenesis, including DNA repair, immune function, and cell cycle control. We will analyze tumor samples for mutations in a range of tumor suppressor genes and oncogenes. |