Z01 CP010131-04020 (Z01) | |||
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Title | Cancer following bone-marrow transplantation | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Ron, Elaine | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $144,313 | Project Dates | 10/01/1992 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Bone Marrow Transplantation (100.0%) Cancer (100.0%) Childhood Cancers (25.0%) |
Brain (5.0%) Breast Cancer (5.0%) Buccal Cavity (5.0%) Childhood Leukemia (25.0%) Head and Neck (15.0%) Hodgkins disease (10.0%) Leukemia (25.0%) Lymphoma (10.0%) Melanoma (5.0%) Non Hodgkins Lymphoma (20.0%) Salivary Glands (5.0%) Sarcoma (10.0%) Sarcoma, Bone (Sarcoma Subset) (5.0%) Sarcoma, Soft (Sarcoma Subset) (5.0%) Skin (10.0%) Thyroid (5.0%) |
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Research Type | |||
Systemic Therapies - Clinical Applications Surveillance |
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Abstract | |||
Bone marrow transplantation (BMT) has been an increasingly successful treatment for patients with high-risk leukemia, lymphoma and other malignant and non-malignant diseases. Evaluation of BMT patients demonstrated an increased risk of Hodgkin's disease after BMT, with most cases related to Epstein-Barr virus. A separate evaluation of more than 3,000 children undergoing BMT found an over 40-fold risk of new cancers, with radiation and immune dysfunction identified as strong risk factors. |