ZIA CP010150 10825 (ZIA) | |||
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Title | Cancer risk in HIV-exposed uninfected children related to early-life exposure to | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Engels, Eric | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $17,044 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Childhood Cancers (50.0%) |
Brain (50.0%) Childhood Leukemia (50.0%) Leukemia (50.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Systemic Therapies - Clinical Applications |
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Abstract | |||
Antiretroviral (ART) medications are used to prevent transmission of HIV from HIV-infected mothers to their children, but the longterm effects of exposure to ART in utero and in early life are incompletely understood. As part of the HIV/AIDS Cancer Match Study, the researchers will collaborate with staff at multiple state HIV and cancer registries in the US, to perform a computerized linkage of databases for HIV-exposed uninfected (HEU) children. Cancer risk in HEU children will be compared to cancer risk in the general population. Investigators will also compare cancer risk in HEU children exposed to specific ART medications. NIH researchers will not receive personal identifiers from HIV or cancer registries. |