ZIA CP010136-10669 (ZIA) | |||
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Title | A pooled investigation of adiponectin and multiple myeloma | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hofmann, Jonathan | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $12,905 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Multiple Myeloma (100.0%) | ||
Research Type | |||
Cancer-Related Biology
Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"""It has been hypothesized that the observed excess risk of multiple myeloma (MM) among obese individuals could be due to altered circulating levels of adiponectin, a polypeptide hormone with anti-inflammatory properties secreted by adipose tissue. In a recent prospective investigation in PLCO, we observed inverse associations with MM for both total and high-molecular-weight (HMW) adiponectin. The results of this study, to our knowledge the first prospective investigation of circulating adiponectin and MM, suggest that this hormone may play a role in obesity-related myelomagenesis. Replication of this finding in other prospective cohorts is critical. We conducted a pooled nested case-control study of MM risk in relation to total and HMW adiponectin using prospectively collected blood samples from cohorts participating in the NCI Cohort Consortium. We also investigated MM risk in relation to circulating levels of resistin, another hormone secreted by adipose tissue, in a subset of three participating cohorts. """ |