ZIA CP010133-04041 (ZIA) | |||
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Title | Dosimetry Projects | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Bouville | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $285,181 | Project Dates | 07/01/2003 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Head and Neck (80.0%) Thyroid (80.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Development and Characterization of Model Systems |
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Abstract | |||
(1) Chornobyl Study of Leukemia: The aims of the dosimetry effort are to provide accurate, individual bone-marrow doses for all cases and controls, and to assess the uncertainties in the bone-marrow dose estimates. Most of the dose resulted from external irradiation from the radionuclides deposited on the ground and building materials. A time-and-motion method of dose reconstruction, called RADRUE, is used to estimate the individual bone-marrow doses for all study subjects. The application of this method requires a detailed knowledge of the radiation field, as a function of time after the accident, for multiple locations, and the itineraries followed by the clean-up workers while they were exposed to radiation in or near the power plant. The main advantage of this method versus other validation methods is that it can be applied to living and deceased subjects for any dose level. (2) The U.S. Radiologic technologists study: Technologists received exposure from performing diagnostic and therapeutic procedures utilizing techniques of static radiography, preparation and application of radiopharmaceuticals, radiation therapy, and other nuclear medicine procedures. Routine monitoring for radiation exposure of medical personnel in radiology increased over time, with the most progressive hospitals initiating routine individual monitoring as early as the late 1940s. Exposures decreased over time owing to improvements in technology and protection measures. The goal of the dosimetry group is to reconstruct historical doses, estimating annual and cumulative total body and specific organ doses for each technologist, on the basis of the available badge readings. Organs of interest include: female breast, red bone marrow, thyroid, and skin. |