ZIA CP004410 08285 (ZIA) | |||
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Title | Families at high risk of cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Savage, Sharon | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $76,748 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Autoimmune Diseases (15.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Neurofibromatosis (7.0%) Childhood Cancers (20.0%) |
Brain (10.0%) Breast (1.0%) Eye (9.0%) Kidney Cancer (5.0%) Kidney Disease (5.0%) Leukemia (15.0%) Lung (5.0%) Melanoma (5.0%) Multiple Myeloma (1.0%) Pharynx (5.0%) Stomach (2.0%) Urinary System (10.0%) Head and Neck (5.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
Investigations of families and individuals at high risk of cancer often lead to etiologic clues that may be important in the general population. Families with multiple members who have an unusual pattern or number of cancers are evaluated clinically and risk factor information is obtained. When specific genetic alterations or host characteristics predicting risk are identified, population studies are conducted to assess these factors outside of high-risk families. Studies of individuals at high risk because of specific exposures (i.e., radiation or chemotherapy) also yield important information about cancer causation. Most of these investigations have clinical, epidemiologic, and molecular components. Most recently whole exome sequencing and related approaches are being used to identify and characterize inherited variation in these families. |