ZIA BC 011728 (ZIA) | |||
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Title | Cell-cell communications create robust collective immunological responses | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Altan-Bonnet, Gregoire | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $198,401 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Interferon (25.0%) |
N/A | ||
Research Type | |||
Vaccines Systemic Therapies - Discovery and Development |
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Abstract | |||
We developed quantitative models of the cell-to-cell communications via cytokines amongst population of T lymphocytes. Our goal is to understand how T cells self-organize to decide their cell fate (e.g. between quiescence -tolerance- and death/proliferation -responses). At a fundamental level, we developed theoretical tools to analyze the heterogeneity and synchronicity of T cell responses in dense tissues. In the context of responses to tumor, we found that a critical mass of T cells existed to drive tumor rejection. Additional work is being carried out to dissect quantitatively how T cell decide collectively between tumor rejection and tumor tolerance. |