Title |
Multimodal microscope for intraoperative assessment of breast surgical margins
|
Institution |
PHYSICAL SCIENCES, INC, ANDOVER, MA
|
Principal Investigator |
IFTIMIA, NICUSOR
|
NCI Program Director |
Narayanan
|
Cancer Activity |
Small Business - Cancer Detection/ Diagnosis/ Prog
|
Division |
SBIRDC
|
Funded Amount |
$539,569
|
Project Dates |
07/08/2014 - 07/31/2019
|
Fiscal Year |
2018
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
Surgery (100.0%)
|
Breast (100.0%)
|
Research Type |
Technology Development and/or Marker Discovery
Localized Therapies - Discovery and Development
|
Abstract |
Project Summary/Abstract Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) and Caliber ID, Rochester, NY proposes to develop a novel technology for real-time assessment of surgical margins on breast cancer lumpectomy specimens and provide immediate feedback to the surgeon. A multimodal microscope will be used in conjunction with a high sensitivity cancer targeting agent to detect positive margins on lumpectomy specimens. Enhanced contrast fluorescence imaging will be first applied to identify potentially positive margins, while combined high-resolution confocal microscopy-optical coherence tomography imaging will be then used to visualize tissue morphology at the sub-cellular scale and confirm or rule out cancer presence. In Phase I we demonstrated the suitability of this technology for positive cancer margins detection on surgical specimens in a benchtop study. Based on Phase I observations and conclusions we propose to further improve this technology in Phase II and perform a larger scale clinical validation study at the MD Anderson Cancer Center, Houston, TX. Furthermore, a commercialization strategy for this technology will be developed and preliminary steps towards reaching this goal will be taken." |