ZIA CP010132-04109 (ZIA) | |||
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Title | Skin cancer in radiologic technologists | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Linet, Martha | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $30,475 | Project Dates | 12/01/1999 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Radiation - Ionizing - Total (100.0%) Radiation - Ionizing Low Level (100.0%) Radiation - Non Ionizing - Total (100.0%) |
Melanoma (30.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The goal of this study is to assess the effects of ionizing radiation and ultraviolet radiation exposures, jointly or separately, on non-melanocytic cancer of the skin in the US radiologic technologist cohort. Previous analysis of work-history indicated an elevated risk of basal cell carcinoma of the skin, but not that of squamous cell carcinoma, associated with radiation exposure in this cohort. Individual estimates of work-related exposure to ionizing radiation, which are currently being developed, will quantify the radiation-related risk estimates. Pilot studies are also underway, in collaboration with investigators at the Dartmouth University and Harvard University, to assess the validity of questionnaire-based UV exposures and to generate genetic hypotheses to be tested for studies of ionizing and UV-radiation interactions. |