ZIA CP010119-02075 (ZIA) | |||
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Title | Corn Farming Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Beane Freeman, Laura | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $37,838 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Pesticides (60.0%) |
Leukemia (10.0%) Multiple Myeloma (15.0%) Non Hodgkins Lymphoma (70.0%) Thyroid (5.0%) |
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Research Type | |||
Cancer-Related Biology
Exogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"""Factors that contribute to the excess risk farmers have of non-Hodgkin lymphoma (NHL) and other certain hematopoeitic cancers have not been discerned. Many epidemiologic studies have observed an increased risk of NHL among farmers who are exposed to certain pesticides (phenoxyacetic acids, organophosphates, organochlorines, and triazines), but these studies have not been conclusive. In addition, a clear mechanistic association between farming or pesticide exposures and subsequent development of cancer had not been identified. It has been hypothesized that altered immune function may be an indicator of increased potential for the development of immunologically based diseases such as NHL. Research into early immunologic effects of farming exposures holds some promise in discerning disease mechanisms and in identifying specific etiologic agents for lymphatic cancer such as NHL. This study evaluates the changes in immune parameters in farmers throughout the growing season, as well as effects of specific pesticide exposures including atrazine and organophosphate (OP) insecticides. Biological sampling before or after planting and application of preemergent pesticides (likely to include atrazine and possibly OPs or carbamates) will allow examination of short-term biologic effects associated with specific pesticide exposures and general planting activities (e.g., tilling). Post-harvest and off-season samples will also be collected to allow evaluation of overall immune effects of farming activities. Pesticide exposures (e.g., atrazine, Ops, and potentially 2,4-D or carbamates) will be assessed primarily by measurement of the parent compound or its metabolites in urine, and additional information on farming activities and work practices will be obtained by questionnaire. Farmers will serve as their own self-controls, and a selected control group will provide a means for external comparison.""" |