ZIA CP010136-00415 (Z1A) | |||
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Title | Pancreatic cancer in blacks and whites | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Silverman, Debra | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $2,920 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (10.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Pancreas (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Epidemiologic research is being conducted to identify factors that play a role in the etiology of pancreatic cancer and contribute to the high rates experienced by African-Americans. We conducted a population-based, case-control study in the United States based exclusively on direct subject interviews with more than 500 cases and 2100 controls. Our findings have solidified the causal link between cigarette smoking and risk of pancreatic cancer, but it explained little of the excess risk seen for blacks. Our results also indicated that consumption of alcohol at levels typically consumed by the general U.S. population is probably not a risk factor for pancreatic cancer, but heavy alcohol drinking may increase risk. As much as one-third of the black/white difference in men, and one-half the difference in women may be attributable to heavy alcohol consumption. Further, we found that obesity is a risk factor for pancreatic cancer and appears to contribute to the higher risk among blacks than whites in the United States, particularly among women. Other potential risk factors for pancreatic cancer under investigation in the case-control study include medical conditions, family history of the cancer, occupational exposures, and socioeconomic status." |