ZIA CP010150 10817 (ZIA) | |||
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Title | New Virus Identification | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Engels, Eric | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $1,179 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Organ Transplantation Research (100.0%) |
Non Hodgkins Lymphoma (50.0%) Urinary System (50.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
We are conducting two sequencing studies to determine the role of two types of oncogenic viruses and their respective cancers. Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma with unknown etiology. We are utilizing next generation sequencing to identify viruses present in ALCL tumor tissues. Based on the strong elevation in immunosuppressed populations, we hypothesize that at least some cases of ALCL are caused by a virus. We will use next generation sequencing methods to agnostically search for viruses in ALCL tumor tissue. The possibility that BK polyomavirus causes a fraction of urothelial cancers could have important scientific and clinical implications. The present study will obtain archived tumor tissue from bladder cancer cases affecting transplant recipients, and assess these cases for evidence of a causal role for BKV in tumor development. We will Perform whole genome sequencing (WGS) on bladder cancers (and matched normal tissue when possible) from solid organ transplant recipients to: 1. Characterize the frequency and integration status of BKV in tumors. 2. Identify the APOBEC damage status of the BKV genome in BKV+ tumors. 3. Compare human genomic characteristics in BKV+ and BKV- tumors, including the presence of mutations in oncogenes or tumor suppressor genes, and APOBEC3 signature mutations. |